Ballistic BERBERINE SUPERCYCLO, 90 Capsules

Berberine SuperCyclo™ (Berberine-Cyclodextrin complex): Berberine has been shown to be a very effective glucose disposal agent (GDA) in several studies. Berberine increases glucose-stimulated insulin secretion and inhibits α-glucosidase activities, as well as promoting glucose uptake in muscle cells. It works by increasing phosphorylation of the insulin receptor, insulin receptor substrate- 1, and protein kinase B. But Berberine’s main mechanism is through activation of Adenosine Monophosphate-Activated Protein Kinase (AMPK) while inhibiting the enzyme Protein-Tyrosine Phosphatase 1B (PTP1B), an enzyme that down regulates the insulin pathway which can also lead to insulin resistance and the resulting increased storage of glucose as fat.  For the muscle cells to increase their access to obtaining energy, they trigger the activity of AMPK enzymes. This enzyme then facilitates the uptake of glucose and fatty acids from the blood and delivers it to the cells. Due to this enzyme, the breakdown of glycogen and fat is excessively increased which prevents the excessive storage of fat and glycogen.  A great feature of Berberine is that it will only reduce blood sugar levels if they are elevated.   

The main drawback with regular Berberine is that the bioavailability is extremely low. Only about 0.36% of orally ingested regular Berberine can enter the systemic circulation. 

Now there’s no need to waste your money on regular, hard to absorb, and ultimately ineffective Berberine!

Berberine SuperCyclo™ from B1 by Ballistic® is Berberine complexed with beta-cyclodextrin.  Cyclodextrins are sugar molecules bound into a ring- or doughnut-shape, which can be used to increase the solubility of other insoluble compounds.  The insoluble compound is held in the hydrophobic cavity, and the cyclodextrin acts as a water-soluble “carrier” molecule. This makes Berberine SuperCyclo™ more soluble leading to more than double the absorbability rate of normal Berberine.